Genetic Predisposition of Autoimmune Disease and B-Cell Chronic Lymphocytic Leukemia (B-CLL).
نویسندگان
چکیده
منابع مشابه
Genetic predisposition of autoimmune disease and B-cell chronic lymphocytic leukemia (B-CLL).
Autoimmune disease is a polygenic disease in which various genetic factors play crucial roles. The familial clustering and the association of HLA haplotypes have been well-recognized. There is a close association between chronic lymphocytic leukemia (CLL) and autoimmune disease. Like autoimmune diseases, CLL is the type of leukemia most often occurring among close relatives. The patients with C...
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The expression of HLA-G was reported in certain malignancies and its role in escaping from immunosurveillance in cancers was proposed since HLA-G is a nonconventional HLA class I molecule that protects fetus from immunorecognition during pregnancy. Recent studies proposed HLA-G as novel prognostic marker for patients with B-CLL. HLA-G was showed to bear even better prognostic information compar...
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The most frequent chromosomal aberrations in B-cell chronic lymphocytic leukemia (B-CLL) are deletions on 13q, 11q, and 17p, and trisomy 12, all of which are of prognostic significance. Conventional cytogenetic analysis and fluorescence in situ hybridization (FISH) are used for their detection, but cytogenetic analysis is hampered by the low mitotic index of B-CLL cells, and FISH depends on acc...
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ژورنال
عنوان ژورنال: The Tohoku Journal of Experimental Medicine
سال: 1994
ISSN: 0040-8727,1349-3329
DOI: 10.1620/tjem.173.133